Regulatory T Cells and Immune Tolerance

نویسندگان

  • Shimon Sakaguchi
  • Tomoyuki Yamaguchi
  • Takashi Nomura
  • Masahiro Ono
چکیده

Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease.

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عنوان ژورنال:
  • Cell

دوره 133  شماره 

صفحات  -

تاریخ انتشار 2008